Mlle de Lubert was the eldest of two daughters and a son of Louis de Lubert (a president of the 3rd Chamber of Inquiries of the Parliament of Paris) and his wife, Marie-Madeleine Perrot (daughter of the governor of Acadia). She was born in Paris on December 17, 1702 and died on August 20, 1785 in Argentan, where her brother lived.

Mlle de Lubert was named Marie-Madeleine after her mother. Never married, she devoted her life to literature and the arts. She corresponded with Voltaire, who wrote a poem in her honor. Her small but select circle of friends in Paris included Charles Marie de La Condamine (French naturalist, explorer, and writer), Jean François Durey de Mesnières (a parliamentary president and journalist), and Madame de Graffigny (a novelist, playwright, and salon hostess who supported the education of women).

Mlle de Lubert wrote about a dozen novels or contes de fées (fairy stories). Tecserion, her first published book, takes place on the planet Venus (1737). The publication of a number of her books in 1743, during the exile of the Parliament from Paris, may have aided the family finances. Her best known contes des fées are La princess Camion (1743), Le prince Glacé et la princesse Etincelante (1743), and La princesse Coque d'Œuf et le prince Bonbon (1745). The attributions of the latter and of two other works, La princess Sensible et le prince Typhon (1743) and the Histoire secrete du Prince Croqu'tron et de la princesse Foirette (not published until 1873), to Mlle de Lubert are problematic. Her writings are late examples of the contes de fées genre.