The documents in this collection concern the Wyandot tribe who departed Ohio in 1843, relocating in what became Kansas Territory. Most of the collection consists of letters to and from prominent members of the Wyandots who relocated from Ohio, including William Walker, Jr., his brother Joel, John W. Grey Eyes, and Wyandot Indian Agent John Johnston.

The collection includes letters of Wyandot chiefs and principals of the Wyandot Nation. Also, there is correspondence about the Methodist Church Mission effort among the Wyandots involving the division of the Methodist Church North and South. The documents in the collection include several Wyandot land allotments to the tribe in Kansas territory. An item by item inventory is included in each folder.